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12 attractions selected in this guide.

Teatro alla Scala is the most prestigious opera house in the world. Since its inauguration in 1778, virtually every great opera composer and performer has graced its legendary stage.

The Galleria Vittorio Emanuele II is one of the world's oldest and most elegant shopping arcades, a soaring cruciform gallery of iron and glass connecting Piazza del Duomo to Piazza della Scala.

Leonardo da Vinci's The Last Supper (Il Cenacolo) is a 4.6 by 8.8-meter mural painted on the refectory wall of Santa Maria delle Grazie. It is arguably the most famous painting in the world after the Mona Lisa.

The Basilica di Sant'Ambrogio is Milan's most revered church, founded in 379 AD by the city's patron saint, Ambrose. Its Romanesque architecture set the template for Lombard churches across northern Italy.

The Duomo di Milano is the largest Gothic cathedral in Italy and the third-largest church in the world. Its forest of 135 marble spires, 3,400 statues, and gleaming Candoglia marble facade took nearly six centuries to complete.

The Cimitero Monumentale is Milan's grand open-air museum of funerary art, where the city's wealthiest industrialists and artists commissioned extraordinary tombs and sculptures from the late 19th century onward.

San Bernardino alle Ossa is a small church near the Duomo containing a macabre ossuary chapel whose walls and ceiling are entirely decorated with human skulls and bones.

Walking atop the Duomo di Milano's rooftop terraces places you among a forest of 135 intricately carved Gothic spires, with panoramic views stretching to the Alps on clear days.
Often called Milan's Sistine Chapel, San Maurizio al Monastero Maggiore is a small 16th-century church whose interior is completely covered in breathtaking Renaissance frescoes by Bernardino Luini and his pupils.

The Colonne di San Lorenzo are 16 ancient Roman Corinthian columns standing in front of the Basilica of San Lorenzo Maggiore, one of the few visible remnants of Roman Mediolanum.

The Castello Sforzesco is a massive 15th-century fortress at the heart of Milan, housing several important museums including Michelangelo's final sculpture, the Rondanini Pieta.

The Arco della Pace is a grand neoclassical triumphal arch marking the northwest entrance to Parco Sempione, inspired by the Arc de Triomphe in Paris.