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San Siro is traditionally considered Genoa's oldest church, founded in the 4th century as the first cathedral before the seat was moved to San Lorenzo. The current building is a 16th–17th-century baroque reconstruction, but its dark, atmospheric interior evokes centuries of worship.
According to tradition, San Siro was founded in the 4th century by Bishop Siro, Genoa's first bishop and patron saint. It served as the city's cathedral until 1007. The medieval church was destroyed by fire in 1580 and rebuilt in baroque style by the Theatine order.